Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist. It is one of the most studied peptides in metabolic and weight management research.

Benefits

• Significant reduction in body weight and appetite
• Improvement in blood glucose control and insulin sensitivity
• Reduction in food cravings and overall calorie intake
• Support for fat loss while preserving lean muscle mass
• Improvement in lipid profile and cardiovascular markers
• Potential reduction in liver fat
• Enhanced satiety and feelings of fullness
• Support for better metabolic health and energy regulation
• Potential neuroprotective effects in metabolic models
• Improvement in glycemic variability

Dosing Schedule

A common simple protocol used in laboratory studies starts with 0.25 mg of Semaglutide once per week, administered subcutaneously. The dose is then titrated upward by 0.25–0.5 mg every 4 weeks until the individual researcher reaches a comfortable maintenance level. Maintenance dosing is subjective and based on personal response and tolerance.

Suggested maintenance dose based on BMI (once per week):

• BMI 20-21: 0.5 mg
• BMI 22-23: 0.75 mg
• BMI 24-25: 1.0 mg
• BMI 26-27: 1.25 mg
• BMI 28-29: 1.5 mg
• BMI 30-31: 1.75 mg
• BMI 32-33: 2.0 mg
• BMI 34-35: 2.25 mg
• BMI 36-37: 2.5 mg
• BMI 38+: 2.5–3.0 mg

Reconstitution Instructions

For 10mg vial:

• Add 2 mL of bacteriostatic water → concentration = 5 mg/mL
• 0.5 mg dose = 10 units (0.10 mL)

For 20mg vial:

• Add 2 mL of bacteriostatic water → concentration = 10 mg/mL
• 0.5 mg dose = 5 units (0.05 mL)

Storage

• Unreconstituted vials: Store in a cool, dry place or refrigerator.
• After reconstitution: Refrigerate the solution and use within 30 days. Do not freeze.